-
Product Name
CYP4F11 antibody
- Documents
-
Description
CYP4F11 Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer. Positive WB detected in human liver tissue, human kidney tissue. Observed molecular weight by Western-blot: 57kd
-
Tested applications
ELISA, WB, IHC
-
Species reactivity
human; other species not tested.
-
Alternative names
CYP4F11 antibody; CytOChrome P450 4F11 antibody; CYPIVF11 antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of CYP4F11 recombinant protein (Accession Number: NM_021187). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
-
Validations
human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:109705(CYP4F11 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:109705(CYP4F11 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:109705(CYP4F11 antibody) at dilution of 1:100 (under 40x lens)
-
Background
CYP4F11, also named as CYPIVF11, belongs to the cytochrome P450 family. It is the lone CYP4F/A enzyme that effectively oxidized 3-hydroxypalmitate. It is the predominant catalyst of this fatty acid oxidation reaction in human liver. CYP4F11 is one of the primary human epidermal keratinocytes. It is positively regulated by multiple signaling pathways in HaCaT keratinocytes, including RXR and JNK signaling pathways. (PMID:19812349)
-
References
- Wang Y, Bell JC, Keeney DS, Strobel HW. Gene regulation of CYP4F11 in human keratinocyte HaCaT cells. Drug metabolism and disposition: the biological fate of chemicals. 38(1):100-7. 2010.
- Bell JC, Strobel HW. Regulation of cytochrome P450 4F11 by nuclear transcription factor-κB. Drug metabolism and disposition: the biological fate of chemicals. 40(1):205-11. 2012.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"