Cyclin T1 antibody

Cyclin T1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Cyclin T1 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, A431 cells, HeLa cells, Jurkat cells, Y79 cells. Observed molecular weight by Western-blot: 87 kDa

ELISA, WB

Human,Mouse,Rat; other species not tested.

CCNT antibody; CCNT1 antibody; Cyclin T antibody; cyclin T1 antibody; CYCT1 antibody; HIVE1 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_001240). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CCNT1, also named as CycT1, belongs to the cyclin family and Cyclin C subfamily. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex which also called positive transcription elongation factor B (P-TEFb). In case of HIV or SIV infections, CCNT1 binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). CCNT1 serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. The antibody is specific to CCNT1.

• Eilebrecht S, Le Douce V, Riclet R. HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters. Nucleic acids research. 42(8):4962-71. 2014.