CUL7 antibody

CUL7 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CUL7 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, A431 cells. Positive IHC detected in human heart tissue, human skeletal muscle tissue. Observed molecular weight by Western-blot: 185kd

ELISA, WB, IHC

Human, Mouse; other species not tested.

CUL 7 antibody; CUL7 antibody; cullin 7 antibody; dJ20C7.5 antibody; KIAA0076 antibody

Rabbit IgG

This antibody was obtained by immunization of CUL7 recombinant protein (Accession Number: NM_014780). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The cullin family proteins are scaffold proteins for the Ring finger type E3 ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. Humans express seven cullin proeins: CUL1–3, CUL4A, CUL4B, CUL5, and CUL7. Each cullin protein can form an E3 ligase similar to the prototype Ring-type E3 ligase Skp1-CUL1-F-box complex. The Cullin-RING-finger type E3 ligases are important regulators in early embryonic development, as highlighted by genetic studies demonstrating that knock-out of CUL1, CUL3, or CUL4A in mice results in early embryonic lethality. CUL7 was originally discovered as 185-kDa protein associated with the large T antigen of simian virus 40 (SV40). CUL7-deficient mice exhibit neonatal lethality with reduced size and vascular defects. CUL7 presumably plays a role in the DNA damage response by limiting p53 activity. CUL7 mutations have also been identified in 3-Msyndrome and the Yakuts short stature syndrome, both of which are characterized by pre- and post-natal growth retardation but with relatively normal mental and endocrine functions, suggesting that CUL7 may also be crucial for human placental development.

• Zhang W, Wang Q, Song P, Zou MH. Liver kinase b1 is required for white adipose tissue growth and differentiation. Diabetes. 62(7):2347-58. 2013.