CUL4A antibody

CUL4A antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CUL4A Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue.

ELISA, IHC

Human; other species not tested.

CUL 4A antibody; CUL4A antibody; cullin 4A antibody; Cullin-4A antibody

Rabbit IgG

This antibody was obtained by immunization of CUL4A recombinant protein (Accession Number: NM_001008895). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Cullin proteins assemble a large number of RING E3 ubiquitin ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. Two cullin 4 (CUL4) proteins, CUL4A (87 kDa) and CUL4B(104 kDa), have been identified. The two CUL4 sequences are 83% identical. They target certain proteins for degradation by binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex with DDB. They form two individual E3 ligases, DDB1-CUL4ADDB2 and DDB1-CUL4BDDB2 in this process. CUL4A appeared in both the nucleus and the cytosol, suggesting a more complex mechanism for entering the nucleus. CUL4B is localized in the nucleus and facilitates the transfer of DDB1 into the nucleus independently of DDB2. This antibody can bind both CUL4A and CUL4B.

• Melchor L, Saucedo-Cuevas LP, Muñoz-Repeto I. Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes. Breast cancer research : BCR. 11(6):R86. 2009.