CSPG4,NG2 antibody

CSPG4,NG2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CSPG4,NG2 Rabbit Polyclonal antibody. Positive IHC detected in human lung cancer tissue. Positive WB detected in A375 cells. Observed molecular weight by Western-blot: 240-250kd

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

CSPG4 antibody; HMW MAA antibody; MCSP antibody; MCSPG antibody; MEL CSPG antibody; MSK16 antibody; NG2 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_001897). Purification method: Antigen affinity purified.

Polyclonal

0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CSPG4, also named as HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16 and NG2, is a proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. CSPG4 may inhibit neurite outgrowth and growth cone collapse during axon regeneration. It is cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. CSPG4 may regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. It modulates the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. CSPG4 functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. It promotes retraction fiber formation and cell polarization through Rho GTPase activation and stimulates alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. CSPG4 activates FAK and ERK1/ERK2 signaling cascades. The antibody is specific to CSPG4.

• Steinberg F, Gallon M, Winfield M. A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Nature cell biology. 15(5):461-71. 2013.