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Product Name
COX10 antibody
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Description
COX10 Rabbit Polyclonal antibody. Positive WB detected in A549 cells, mouse colon tissue, rat colon tissue. Observed molecular weight by Western-blot: 51 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
COX10 antibody; Heme O synthase antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of COX10 recombinant protein (Accession Number: NM_001303). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:109482(COX10 antibody) at dilution of 1:300
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Background
Cytochrome c oxidase (COX) is the terminal enzyme in the electron transfer chain located in the mitochondrial inner membrane. It catalyzes the electron transfer from reduced cytochrome c to oxygen. COX10 is predicted to contain 7-9 transmembrane domains, and it is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. In addition, COX10 may play a certain role in the development and progression of azoospermia.
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References
- Dassa EP, Dufour E, Gonçalves S. Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells. EMBO molecular medicine. 1(1):30-6. 2009.
- Sung HJ, Ma W, Wang PY. Mitochondrial respiration protects against oxygen-associated DNA damage. Nature communications. 1:5. 2010.
- Colleoni F, Padmanabhan N, Yung HW. Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibition. PloS one. 8(1):e55194. 2013.
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