Cart 2

Coproporphyrinogen oxidase antibody

Cat.#: 109460

Size:

Special Price 239.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Coproporphyrinogen oxidase antibody
  • Documents
  • Description
    Coproporphyrinogen oxidase Rabbit Polyclonal antibody. Positive IHC detected in human medulloblastoma tissue, human liver tissue. Positive IP detected in HepG2 cells. Positive WB detected in human liver tissue, HepG2 cells, Jurkat cells, K-562 cells. Observed molecular weight by Western-blot: 36kd
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Coprogen oxidase antibody; Coproporphyrinogen oxidase antibody; Coproporphyrinogenase antibody; COX antibody; CPO antibody; CPOX antibody; CPX antibody; HCP antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Coproporphyrinogen oxidase recombinant protein (Accession Number: NM_000097). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:1000-1:10000

    IP: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:109460(CPOX antibody) at dilution of 1:500

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:109460(CPOX antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human medulloblastoma using Catalog No:109460(CPOX antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human medulloblastoma using Catalog No:109460(CPOX antibody) at dilution of 1:100 (under 10x lens)

    IP Result of anti-CPOX (IP:Catalog No:109460, 4ug; Detection:Catalog No:109460 1:500) with HepG2 cells lysate 2400ug.

    IP Result of anti-CPOX (IP:Catalog No:109460, 4ug; Detection:Catalog No:109460 1:500) with HepG2 cells lysate 2400ug.

  • Background
    CPOX(Coproporphyrinogen-III oxidase, mitochondrial) is also named as CPO and CPX. Human CPO is a 76 kDa protein that is active as a homodimer in the mitochondrial intermembrane pace(PMID:16159891).Mutations in human CPO gene predict the clinical outcome of the disease, with either hepatic hereditary coproporphyria or hematological manifestations of erythropoietic harderoporphyria.CPOX has a transit peptide of 110 aa and the chain contains 344 aa.
  • References
    • Takahashi K, Ikeda N, Nonoguchi N. Enhanced expression of coproporphyrinogen oxidase in malignant brain tumors: CPOX expression and 5-ALA-induced fluorescence. Neuro-oncology. 13(11):1234-43. 2011.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"