Claudin 18 antibody

Claudin 18 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Claudin 18 Mouse Monoclonal antibody. Positive IP detected in mouse stomach tissue. Positive IHC detected in human stomach tissue, human ovary tumor tissue, human pancreas cancer tissue. Observed molecular weight by Western-blot: 29 kDa

ELISA, IHC, IP

Human, Mouse; other species not tested.

claudin 18 antibody; CLDN18 antibody; SFTA5 antibody; SFTPJ antibody

Mouse IgG2a

This antibody was obtained by immunization of Claudin 18 recombinant protein (Accession Number: NM_016369). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Claudin 18 (CLDN18) belongs to the large claudin family of proteins, which are tetraspan transmembrane proteins of tight junctions (PMID: 11585919; 18036336). Claudins exhibit specific patterns of expression in different tissues (PMID: 15447685). CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific (PMID: 11585919; 21832145). Altered CLDN18 expression has been reported in various human malignancies, including gastric cancer, lung adenocarcinoma, and pancreatic neoplasm (PMID: 17459057; 22076167; 21832145).