CHRNB1 antibody

CHRNB1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CHRNB1 Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue. Positive WB detected in human liver tissue, mouse liver tissue. Positive IP detected in mouse liver tissue. Observed molecular weight by Western-blot: 50-57 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

ACHRB antibody; CHRNB antibody; CHRNB1 antibody; CMS1D antibody; CMS2A antibody; FLJ57107 antibody; SCCMS antibody

Rabbit IgG

This antibody was obtained by immunization of CHRNB1 recombinant protein (Accession Number: NM_000747). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Acetylcholine receptors (AChRs) are integral membrane proteins that respond to the binding of acetylcholine (ACh), a neurotransmitter synthesized, stored and finally released by cholinergic neurons. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) subunits. CHRNB1 gene encodes acetylcholine receptor subunit beta (ACHRB). Mutations in this gene are associated with slow-channel congenital myasthenic syndrome.

• Qian J, Galitovskiy V, Chernyavsky AI, Marchenko S, Grando SA. Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of naïve CD4 T cells toward the Th1, Th2 and Th17 lineages. Genes and immunity. 12(3):222-30. 2011.