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CGGBP1 antibody

Cat.#: 109202

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Special Price 239.0 USD

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Product Information

  • Product Name
    CGGBP1 antibody
  • Documents
  • Description
    CGGBP1 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, HL-60 cells, K-562 cells, mouse thymus tissue, Raji cells. Positive IHC detected in human prostate cancer. Observed molecular weight by Western-blot: 19-23kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CGGBP1 antibody; CGGBP antibody; p20 CGGBP DNA binding protein antibody; p20 CGGBP antibody; 20 kDa CGG binding protein antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CGGBP1 recombinant protein (Accession Number: BC005222). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:109202(CGGBP1 antibody) at dilution of 1:1000

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:109202(CGGBP1 antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:109202(CGGBP1 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:109202(CGGBP1 antibody) at dilution of 1:100 (under 10x lens)

  • Background
    CGGBP1, also named as CGGBP, is a 20 kDa CGG-binding protein. It binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. CGGBP1 may play a role in regulating FMR1 promoter. It is a bona fide midbody protein required for normal abscission and mitosis in general.(PMID:20832400)
  • References
    • Singh U, Westermark B. CGGBP1 is a nuclear and midbody protein regulating abscission. Experimental cell research. 317(2):143-50. 2011.
    • Singh U, Maturi V, Jones RE, Paulsson Y, Baird DM, Westermark B. CGGBP1 phosphorylation constitutes a telomere-protection signal. Cell cycle (Georgetown, Tex.). 13(1):96-105. 2014.
    • Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y. Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration. International journal of clinical and experimental pathology. 8(12):15836-44. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"