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CES2 antibody

Cat.#: 109193

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Product Information

  • Product Name
    CES2 antibody
  • Documents
  • Description
    CES2 Rabbit Polyclonal antibody. Positive WB detected in human stomach tissue, human liver tissue. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 60kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    Carboxylesterase 2 antibody; CE 2 antibody; CES2 antibody; CES2A1 antibody; hCE 2 antibody; iCE antibody; PCE 2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CES2 recombinant protein (Accession Number: BC032095). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human stomach tissue were subjected to SDS PAGE followed by western blot with Catalog No:109193(CES2 antibody) at dilution of 1:300

    human stomach tissue were subjected to SDS PAGE followed by western blot with Catalog No:109193(CES2 antibody) at dilution of 1:300

    Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:109193(CES2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:109193(CES2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:109193(CES2 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:109193(CES2 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    CES2(Carboxylesterase 2) is also named as ICE and belongs to the type-B carboxylesterase/lipase family. Carboxylesterases (CESs) hydrolyze ester groups of drugs and toxins. CES2 specifically catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl groups of 4-methylumbelliferyl acetate, heroin, and 6-monoacetylmorphine. CES2 differs from another liver carboxylesterase, CES1 (114835), in drug ester substrate specificity. This protein has 2 isoforms produced by alternative splicing
  • References
    • Sato Y, Miyashita A, Iwatsubo T, Usui T. Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals. 40(7):1389-96. 2012.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"