CDR2 antibody

CDR2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CDR2 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, Y79 cells. Positive IHC detected in human breast cancer tissue. Observed molecular weight by Western-blot: 62 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

CDR2 antibody; CDR62 antibody; PCD17 antibody

Rabbit IgG

This antibody was obtained by immunization of CDR2 recombinant protein (Accession Number: XM_005276502). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Patients with paraneoplastic cerebellar degeneration (PCD) carry a characteristic antibody called anti-Yo. On Western blot analysis of Purkinje cells and tumor tissue from CD patient, the anti-Yo sera react with at least 2 antigens, a major species of 62 kD called CDR62 or CDR2 [PMID:18045792]. CDR2 is partly characterized, as CDR2 through its leucine zipper motif has been demonstrated to interact with c-myc, with cell cycle-related proteins and with a protein kinase, indicating that CDR2 is involved in signal transduction and gene transcription. Furthermore, CDR2 has been found to attenuate hypoxic response in renal cell carcinoma, and recent data suggest a role for CDR2 and c-myc in mitosis in cycling cells [PMID:21080165].

• Schubert M, Panja D, Haugen M, Bramham CR, Vedeler CA. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta neuropathologica. 128(6):835-52. 2014.