CDKAL1 antibody

CDKAL1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CDKAL1 Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in mouse lung tissue, HepG2 cells, HT-1080 cells, Jurkat cells. Observed molecular weight by Western-blot: 60-65 kDa

ELISA, WB, IF

Human, Mouse; other species not tested.

CDKAL1 antibody; FLJ20342 antibody; FLJ46705 antibody

Rabbit IgG

This antibody was obtained by immunization of CDKAL1 recombinant protein (Accession Number: NM_017774). Purification method: Antigen Affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Cell cycle progression is controlled, in part, by a family of cyclin dependent kinases (Cdks) that work to phosphorylate key substrates involved in each phase of cell cycle progression. Cdks are the catalytic subunits of serine/threonine protein kinases, a large family of proteins that act as regulators of the eukaryotic cell cycle. CDKAL1 (Cdk5 regulatory subunit associated protein 1-like 1) is a 579 amino acid single-pass membrane protein that contains one TRAM domain and is similar to Cdk5 regulatory subunit associated proteins (CDK5RAPs). Expressed in pancreas, brain and skeletal muscle, CDKAL1 uses iron as a cofactor and is involved in glucose-stimulated insulin secretion. Defects in the gene encoding CDKAL1 impair insulin secretion and are associated with the development of type 2 diabetes. Multiple isoforms of CDKAL1 exist due to alternative splicing events. This antibody recognizes the 65kd isoform of CDKAL1.