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Product Name
CDCA4 antibody
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Description
CDCA4 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells. Observed molecular weight by Western-blot: 33kd
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
CDCA4 antibody; FLJ20764 antibody; FLJ52878 antibody; HEPP antibody; SEI 3/HEPP antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CDCA4 recombinant protein (Accession Number: NM_017955). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:109115(CDCA4 antibody) at dilution of 1:500
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Background
TRIP-Br proteins are a set of proteins with the potential to function in both transcriptional control and cell cycle regulation [PMID:18572021]. CECA4 is a member of TRIP-br family, based on its homologous sequence motifs including SERTA and a PHD-bromo-binding site which interacts with a series of bromodomain containing transcriptional cofactors[PMID:17141982]. When activated by E2F, CDCA4 consequently functions as a suppressor of E2F-responsive promoters to participate the regulation of cell proliferation through the E2F/pRb pathway [PMID:16098148].
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References
- Klein U, Lia M, Crespo M. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer cell. 17(1):28-40. 2010.
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