CDC25C antibody

CDC25C antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CDC25C Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, HepG2 cells, Raji cells. Positive IP detected in K-562 cells. Observed molecular weight by Western-blot: 53 kDa

ELISA, WB, IP

Human; other species not tested.

CDC25 antibody; CDC25C antibody; M phase inducer phosphatase 3 antibody

Rabbit IgG

This antibody was obtained by immunization of CDC25C recombinant protein (Accession Number: XM_047417952). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The cell division cycle 25 (CDC25) family of proteins are highly conserved dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. CDC25C(cell division cycle 25 homolog C) is one of the 3 isoforms of CDC25 in mammalian cells. It is present in the cytoplasm of asynchronously growing human cells(PMID:10330186). And it may be phosphorylated by its own substrate, an active cdc2-cyclin B complex, to create an autoactivation loop(PMID:7937793). It can be hyperphosphorylated to get the active form of 70 kDa(PMID:18296513).

• Zhan W, Han T, Zhang C. TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins. PloS one. 10(11):e0142596. 2015.