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Product Name
CD11c/Integrin alpha X antibody
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Description
CD11c/Integrin alpha X Mouse Monoclonal antibody. Positive WB detected in human spleen tissue. Positive IHC detected in human tonsillitis tissue. Observed molecular weight by Western-blot: 145 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse; other species not tested.
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Alternative names
CD11C antibody; Integrin alpha X antibody; ITGAX antibody; Leu M5 antibody; SLEB6 antibody
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Isotype
Mouse IgG2a
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Preparation
This antibody was obtained by immunization of CD11c/Integrin alpha X recombinant protein (Accession Number: NM_001286375). Purification method: Protein A purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:100-1:400
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Validations
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:107040(CD11c/Integrin alpha X Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:107040(CD11c/Integrin alpha X Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
human spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:107040(CD11c/Integrin alpha X Antibody) at dilution of 1:1000
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Background
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits. CD11c/Integrin alpha X is a type I transmembrane protein present on a variety of cells, including monocytes/macrophages, granulocytes, NK cells and dendritic cells. Integrin alpha X/beta 2 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis.
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References
- Umazume T, Thomas WM, Campbell S. Lacrimal Gland Inflammation Deregulates Extracellular Matrix Remodeling and Alters Molecular Signature of Epithelial Stem/Progenitor Cells. Investigative ophthalmology & visual science. 56(13):8392-402. 2015.
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