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Product Name
CBX1 antibody
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Description
CBX1 Rabbit Polyclonal antibody. Positive IP detected in HEK-293 cells. Positive WB detected in HEK-293 cells, A431 cells, HeLa cells, human brain tissue. Observed molecular weight by Western-blot: 25 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CBX antibody; CBX1 antibody; Chromobox protein homolog 1 antibody; HeterOChromatin protein p25 antibody; HP1 BETA antibody; HP1Hs beta antibody; HP1Hsbeta antibody; M31 antibody; MOD1 antibody; Modifier 1 protein antibody; p25beta antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CBX1 recombinant protein (Accession Number: NM_006807). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:108943(CBX1 antibody) at dilution of 1:1000
IP Result of anti-CBX1 (IP:Catalog No:108943, 3ug; Detection:Catalog No:108943 1:500) with HEK-293 cells lysate 1480ug.
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Background
One function of heterochromatin is the epigenetic silencing by sequestration of genes into transcriptionally repressed nuclear neighborhoods. Heterochromatin protein 1 (HP1) is a major component of heterochromatin and is a candidate for establishing and mediating gene silencing. This protein is expressed in all adult and embryonic tissues, as a homodimer.
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References
- Jiang WQ, Zhong ZH, Nguyen A. Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. The Journal of cell biology. 185(5):797-810. 2009.
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