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CAPG-Specific antibody

Cat.#: 108935

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Product Information

  • Product Name
    CAPG-Specific antibody
  • Documents
  • Description
    CAPG-Specific Rabbit Polyclonal antibody. Positive WB detected in mouse lung tissue, mouse kidney tissue, U-937 cells. Positive IHC detected in human spleen tissue, human stomach cancer tissue. Observed molecular weight by Western-blot: 43kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Actin regulatory protein CAP G antibody; AFCP antibody; CAPG antibody; Macrophage capping protein antibody; MCP antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_001747). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    mouse lung tissue were subjected to SDS PAGE followed by western blot with Catalog No:108935(CAPG-Specific antibody) at dilution of 1:300

    mouse lung tissue were subjected to SDS PAGE followed by western blot with Catalog No:108935(CAPG-Specific antibody) at dilution of 1:300

    Immunohistochemical of paraffin-embedded human spleen using Catalog No:108935(CAPG-Specific antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human spleen using Catalog No:108935(CAPG-Specific antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human spleen using Catalog No:108935(CAPG-Specific antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human spleen using Catalog No:108935(CAPG-Specific antibody) at dilution of 1:50 (under 40x lens)

  • Background
    CapG (gelsolin-like actin-capping protein) is a member of the gelsolin superfamily proteins, which regulates actin filament length by capping or severing filaments. Studies have shown a role for CapG in regulating cell motility. The expression of CapG is upregulated under hypoxia and in turn increases the motility of cells. Recently it has been reported that the overexpression of CapG is associated with the progression of lung adenocarcinoma as well as lyphatic invasion status of cholangiocarcinoma, which may be used for prognosis of these tumors.(21908955,22155129)
  • References
    • Shao F, Zhang R, Don L, Ying K. Overexpression of gelsolin-like actin-capping protein is associated with progression of lung adenocarcinoma. The Tohoku journal of experimental medicine. 225(2):95-101. 2011.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"