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Product Name
Human CAMK1D/CKLiK (GST Tag) recombinant protein
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Description
Calcium/calmodulin-dependent protein kinase or CaM kinases are serine/threonine-specific protein kinases that are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. CaM kinases activity can outlast the intracellular calcium transient that is needed to activate it. In neurons, this property is important for the induction of synaptic plasticity. Pharmacological inhibition of CaM kinases II blocks the induction of long-term potentiation. Upon activation, CaM kinases II phosphorylates postsynaptic glutamate receptors and changes the electrical properties of the synapse.
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Protein name
Calcium/calmodulin-dependent protein kinase ID, isoform CRA_b
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Protein short names
RP23-340A13.1; A630059D12RIK; CAMKIDELTA; CAMKID; CAMK1D; MCKLIK; E030025C11RIK; RP11-462F15.1; CAM-K1; CKLIK
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Uniprot ID
Q8IU85
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Gene Name
CAMK1D; hCG_1811212
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CAMK1D (NP_705718.1) (Met 1-Lys 385) was fused with the GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CAMK1D/GST chimera consists of 610 amino acids and predicts a molecular mass of 69 kDa. It migrates as an approximately 60 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 96 % as determined by SDS-PAGE
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Activity
The specific activity was determined to be 70 nmol/min/mg using Autocamtide-2 synthetic peptide (KKALRRQETVDAL-amide) as substrate (see Activity Assay Protocol)
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Validations
Human CAMK1D / CKLiK Protein (GST Tag) SDS-PAGE
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