C3 / C3b / C3c antibody

Cat.#: 107027

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Product Information

  • Product Name
    C3 / C3b / C3c antibody
  • Documents
  • Description
    C3 / C3b / C3c Mouse Monoclonal antibody. Positive IHC detected in human liver tissue. Positive WB detected in human blood tissue. Observed molecular weight by Western-blot: 115 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    ARMD9 antibody; ASP antibody; C3b antibody; C3c antibody; Complement C3 antibody; complement component 3 antibody; CPAMD1 antibody
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was obtained by immunization of C3 / C3b / C3c recombinant protein (Accession Number: NM_000064). Purification method: Protein G purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:107027(C3 Antibody) at dilution of 1:1000

    human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:107027(C3 Antibody) at dilution of 1:1000

    Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:107027(C3 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:107027(C3 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:107027(C3 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:107027(C3 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    The complement system is an important effector which bridges the innate and adaptive immune systems (PMID: 20010915). The third component of complement, C3, plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways (PMID: 11414361). Human C3, composed of α and β chains (115 and 75 kDa, respectively), is cleaved into C3a and C3b by C3 convertase. C3b is further cleaved into iC3b, C3c, C3dg and C3f. This antibody raised against 1314-1663 aa of human C3 protein recognize C3 alpha chain, C3b alpha' chain, and C3c alpha' chain fragment 2.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"