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Product Name
C1orf31 antibody
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Description
C1orf31 Rabbit Polyclonal antibody. Positive IP detected in HEK-293 cells. Positive WB detected in HEK-293 cells, mouse liver tissue. Observed molecular weight by Western-blot: 10-18 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
C1orf31 antibody; COA6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of C1orf31 recombinant protein (Accession Number: NM_001012985). Purification method: Antigen Affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:108677(C1orf31 antibody) at dilution of 1:1000
IP Result of anti-C1orf31 (IP:Catalog No:108677, 4ug; Detection:Catalog No:108677 1:500) with HEK-293 cells lysate 1760ug.
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Background
C1orf31, also known as COA6, is a conserved mitochondrial protein required for respiratory complex IV biogenesis. Recently study reported that C1orf31 is required for maintenance of cytochrome c oxidase (CcO) subunit levels, and has role in the Cu delivery pathway to CcO. Defects in C1orf31 is associated with mitochondrial respiratory chain disease (MRCD). (24549041)
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References
- Ghosh A, Trivedi PP, Timbalia SA. Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency. Human molecular genetics. 23(13):3596-606. 2014.
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