c-Kit/CD117 antibody

c-Kit/CD117 antibody

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• Material Safety Data Sheets (MSDS)

c-Kit/CD117 Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue, human brain tissue, human heart tissue, human kidney tissue, human lung tissue, human ovary tissue, human placenta tissue, human skin tissue, human spleen tissue, stromal tumor tissue. Positive FC detected in MCF-7 cells. Positive WB detected in MCF7 cells, human brain tissue. Observed molecular weight by Western-blot: 120 kDa, 145 kDa

ELISA, WB, IHC, FC

Human; other species not tested.

C Kit antibody; CD117 antibody; KIT antibody; PBT antibody; Proto oncogene c Kit antibody; SCFR antibody; Tyrosine protein kinase Kit antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_000222). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

KIT, also named as SCFR, c-Kit and CD117, is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. It is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand(SCF) binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Phosphorylation at tyrosine 721 of KIT allows binding and activation of PI3 kinase. Loss of expression of KIT appears to be associated with progression of some tumors (melanoma) and autocrine/paracrine stimulation of the kit/SCF system may participate in human solid tumors such as lung, breast, testicular and gynecological malignancies. Mutations in Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer.