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Product Name
BRIT1 antibody
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Description
BRIT1 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, L02 cells, MDA-MB-453s cells, mouse ovary tissue. Positive IHC detected in human prostate cancer tissue, human kidney tissue. Observed molecular weight by Western-blot: 66 kDa,100 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
BRIT1 antibody; FLJ12847 antibody; MCPH1 antibody; MCT antibody; MicrOCephalin antibody; micrOCephalin 1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of BRIT1 recombinant protein (Accession Number: NM_001172574). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:117237(BRIT1 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:117237(BRIT1 antibody) at dilution of 1:50 (under 10x lens)
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Background
Primary microcdphaly refers to the clinical finding of a head circumference less than 3 standard deviations(SD) below the age- and sex-related mean, present at birth. MCPH1, the fisrt gene identified as causative for primary microcephaly, encodes a multifunctional protein that notably is linked to DNA damage checkpoint, DNA repair by homologous recombination and DNA transcription. MCPH1 is associated with premature chromosome condensation in particular. There are two mainly isoforms encoded by MCPH1 gene, isoform1(~100kd) and isoform2(~66kd)
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"