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Product Name
BRCA2 antibody
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Description
BRCA2 Rabbit Polyclonal antibody. Positive IHC detected in rat brain tissue. Positive WB detected in human brain tissue, HeLa cells. Observed molecular weight by Western-blot: 384kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Rat; other species not tested.
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Alternative names
BRCA2 antibody; BRCC2 antibody; breast cancer 2 antibody; early onset antibody; BROVCA2 antibody; FACD antibody; FAD antibody; FAD1 antibody; FANCB antibody; FANCD antibody; FANCD1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_000059). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:117225(BRCA2 antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded rat brain using Catalog No:117225(BRCA2 antibody) at dilution of 1:50 (under 10x lens)
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Background
BRCA2, also named as FACD and FANCD1, is involved in double-strand break repair and/or homologous recombination. BRCA2 may participate in S phase checkpoint activation. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer (BC) which also called susceptibility to familial breast-ovarian cancer type 2 (BROVCA2).
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References
- Wang Y, Wang Z, Qi Z. The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. Molecular cancer. 13:94. 2014.
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