BORIS antibody

BORIS antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

BORIS Mouse Monoclonal antibody. Positive WB detected in Hela cells, SMMC-7721 cells. Positive IF detected in MCF-7 cells, Hela cells. Observed molecular weight by Western-blot: 75kd

ELISA, WB, IF

Human, Mouse; other species not tested.

BORIS antibody; Cancer/testis antigen 27 antibody; CCCTC binding factor antibody; CT27 antibody; CTCF like protein antibody; CTCF paralog antibody; CTCF T antibody; CTCFL antibody; dJ579F20.2 antibody; Zinc finger protein CTCF T antibody

Mouse IgG1

This antibody was obtained by immunization of BORIS recombinant protein (Accession Number: NM_001269040). Purification method: Caprylic acid/ammonium sulfate precipitation.

Monoclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CTCFL, also named BORIS (for brother of the regulator of imprinted sites) is a paralogue of the 11 zinc-finger transcription factor, CTCF. It is predominantly expressed in spermatocytes in the testis, also can be found in tumors and cancer cell lines. It mainly participates in insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. It has a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2.