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Product Name
BCOR antibody
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Description
BCOR Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells. Observed molecular weight by Western-blot: 186 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ANOP2 antibody; BCOR antibody; FLJ20285 antibody; FLJ38041 antibody; KIAA1575 antibody; MAA2 antibody; MCOPS2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of BCOR recombinant protein (Accession Number: BC009675). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:117108(BCOR antibody) at dilution of 1:400
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Background
BCOR, a corepressor of BCL6, binds to transcriptional factors and specifically inhibits gene expression. BCOR plays a key role in the early embryonic development, mesenchymal stem cell function and hematopiesis. BCOR can associate with HDACs, the polycomb group protein, polycomb group Ring finger protein1/nervous system polycomb1 (PCGF1/NSPC1), histone demethylase, F-box- and leucine-rich repeat protein10(FBXL10). Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem
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References
- Ueno-Yokohata H, Okita H, Nakasato K. Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney. Nature genetics. 47(8):861-3. 2015.
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