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Product Name
ARNTL antibody
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Description
ARNTL Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, 3T3-L1 cells, HT-1080 cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 69-75 kDa
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Tested applications
ELISA, IP, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ARNT3 antibody; ARNTL antibody; bHLH PAS protein JAP3 antibody; bHLHe5 antibody; BMAL1 antibody; BMAL1c antibody; Brain and muscle ARNT like 1 antibody; JAP3 antibody; Member of PAS protein 3 antibody; MOP3 antibody; PASD3 antibody; TIC antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ARNTL recombinant protein (Accession Number: NM_001351804). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:1000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:108160(ARNTL Antibody) at dilution of 1:600
IP Result of anti-ARNTL (IP:Catalog No:108160, 4ug; Detection:Catalog No:108160 1:300) with HeLa cells lysate 1600ug.
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Background
BMAL1, a basic helix–loop–helices with Per–Arnt–Sim (PAS) domain transcription factor, is one of components that has core clock function in mammals. It form a heterodimer with CLocK, and induce the transcription of target genes by binding to E-box elements within their promoter regions. And this transcription is inhibited in a feedback loop by PER, and also by CRY proteins.Also BMAL1 is a key player in the regulation of metabolism, playing a role in adipogenesis and in the control of glucose and triglycerides levels.
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