ARNT2 antibody

ARNT2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ARNT2 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, Jurkat cells, Raji cells. Positive IHC detected in human gliomas tissue. Observed molecular weight by Western-blot: 80-85kd

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

ARNT protein 2 antibody; ARNT2 antibody; bHLHe1 antibody; KIAA0307 antibody

Rabbit IgG

This antibody was obtained by immunization of ARNT2 recombinant protein (Accession Number: BC036099). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Aryl-hydrocarbon receptor nuclear translocator 2(ARNT2), is a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. It specifically recognizes the xenobiotic response element(XRE). ARNT2 plays an important role in normal glucose handling in pancreatic beta cell function in humans and mice. ARNT2 proteins are dimeric partners for other PAS proteins such as HIF and SIM. ARNT2 and the other ARNT family members, e.g., ARNT, hypoxin inducible factor 1α (HIF1α), HIF2α, and aryl hydrocarbon receptor (AhR), are thought to function as heterodimers, and regulate the expression, and thereby the function, of many genes. Under hypoxic conditions, it complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. Modulation of ARNT2 in pancreatic beta cells affects glucose stimulated insulin secretion (GSIS). This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human ARNT2.