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Product Name
ANTXR2 antibody
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Description
ANTXR2 Rabbit Polyclonal antibody. Positive IP detected in HEK-293 cells. Positive WB detected in HEK-293 cells. Positive IHC detected in human ovary tissue, human kidney tissue, human lung tissue, human placenta tissue, human testis tissue. Observed molecular weight by Western-blot: 55 kDa
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Tested applications
ELISA, IHC, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
anthrax toxin receptor 2 antibody; ANTXR2 antibody; CMG 2 antibody; CMG2 antibody; FLJ31074 antibody; ISH antibody; JHF antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ANTXR2 recombinant protein (Accession Number: NM_001286780). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:108109(ANTXR2 Antibody) at dilution of 1:600
Immunohistochemical of paraffin-embedded human ovary using Catalog No:108109(ANTXR2 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human ovary using Catalog No:108109(ANTXR2 antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-ANTXR2 (IP:Catalog No:108109, 4ug; Detection:Catalog No:108109 1:500) with HEK-293 cells lysate 2800ug.
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Background
ANTXR2 (anthrax toxin receptor 2), also known as CMG2 (capillary morphogenesis gene 2 protein) is a transmembrane protein that is induced during capillary morphogenesis. It contains a vWA domain that shows strong binding to laminin and collagen IV, suggesting that this protein plays a role in basement membrane matrix assembly and endothelial cell morphogenesis (PMID: 11683410; 14508707). Like its paralog TEM8 (ANTXR1), ANTXR2 also functions as a receptor for anthrax toxin. Mutations in ANTXR2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis (PMID: 14508707; 12973667; 22383261).
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