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Antizyme inhibitor 1 antibody

Cat.#: 108108

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Product Information

  • Product Name
    Antizyme inhibitor 1 antibody
  • Documents
  • Description
    Antizyme inhibitor 1 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, HEK-293 cells, HepG2 cells, mouse liver tissue, PC-3 cells. Positive IHC detected in human gliomas tissue, human liver tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 49.5 kDa
  • Tested applications
    ELISA, WB, IHC, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Antizyme inhibitor 1 antibody; AZI antibody; AZIN1 antibody; OAZI antibody; OAZIN antibody; ODC1L antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Antizyme inhibitor 1 recombinant protein (Accession Number: XM_047421860). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

    IF: 1:10-1:100

  • Validations

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:108108(AZIN1 antibody) at dilution of 1:500

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:108108(AZIN1 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:108108(AZIN1 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:108108(AZIN1 antibody) at dilution of 1:50 (under 10x lens)

    Immunofluorescent analysis of HepG2 cells, using AZIN1 antibody Catalog No:108108 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

    Immunofluorescent analysis of HepG2 cells, using AZIN1 antibody Catalog No:108108 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

  • Background
    AZIN1(Antizyme inhibitor 1) is also named as OAZI, OAZIN and belongs to the Orn/Lys/Arg decarboxylase class-II family. It catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis, and playing a role in the regulation of polyamine synthesis (negative regulator of cellular polyamines).
  • References
    • Li R, Chung AC, Dong Y, Yang W, Zhong X, Lan HY. The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway. Kidney international. 84(6):1129-44. 2013.
    • Zhu D, Zhang L, Cheng L, Ren L, Tang J, Sun D. Pancreatic Kininogenase Ameliorates Renal Fibrosis in Streptozotocin Induced-Diabetic Nephropathy Rat. Kidney & blood pressure research. 41(1):9-17. 2016.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"