Anti-TNFR2/CD120b/TNFRSF1B antibody

Cat.#: 106517

Special Price 290.3 USD

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Product Information

  • Product Name
    Anti-TNFR2/CD120b/TNFRSF1B antibody
  • Documents
  • Description
    Rabbit monoclonal to TNFR2/CD120b/TNFRSF1B
  • Tested applications
    B/N
  • Species reactivity
    Human TNFRSF1B / TNFR2 / CD120b
    No cross-reactivity with Mouse TNFR2 (504311) in ELISA assay
  • Alternative names
    Tnfbr antibody; p75 antibody; CD120b antibody; CD120b antibody; p75 antibody; p75 TNF receptor antibody; p75 TNFR antibody; p75TNFR antibody; RP23-157J11.1 antibody; TBPII antibody; TNF-alphaR2 antibody; TNFalpha-R2 antibody; TNFBR antibody; Tnfr-1 antibody; TNFR1B antibody; TNFR2 antibody; Tnfr2 antibody; TNF-R2 antibody; TNF-R2 antibody; TNF-R75 antibody; TNF-R75 antibody; TNFR80 antibody; TNFR80 antibody; TNFRII antibody; TNF-RII antibody; TNF-RII antibody; TNFR-II antibody; TNFR-II antibody; TNF-R-II antibody; TNF-R-II antibody; TNFRSF1B antibody; Tnfrsf1b antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF1B / CD120b (rh TNFRSF1B; Met 1-Asp 257; NP_001057.1).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications
    Block - This TNFR2 neutralizing antibody can block the binding of recombinant TNFa to its recombinant receptor TNFRII.
    Neutralization - The neutralization activity of TNFR2/TNFRSF1B Neutralizing Antibody is Measured by its ability to neutralize TNFR2/TNFRSF1B-mediated inhibition of cytotoxicity in the L‑929 mouse fibroblast cell line. The Neutralization titer (IC50) is typically 1-3 µg/mL in the presence of 1 μg/mL Recombinant Human TNFR2/TNFRSF1B, 0.25 ng/mL Recombinant Human TNFa, and 1 µg/mL actinomycin D.
  • Validations

    TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody

    TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody

    TNFR2/TNFRSF1B-mediated inhibition of cytotoxicity was Neutralized by Human TNFR2 Antibody. Recombinant Human TNFR2/TNFRSF1B (Catalog 10417-H08H) inhibits Recombinant Human TNFa (Catalog 10602-HNAE) induced cytotoxicity in the L-929 mouse fibroblast cell line. Inhibition of Recombinant Human TNFa (0.25 ng/mL) activity elicited by Recombinant Human TNFR2/TNFRSF1B (1 µg/mL) is neutralized by increasing concentrations of Human TNFR2/TNFRSF1B Monoclonal Antibody (Catalog 10417-R00N6). The IC50 is typically 1-3 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL).

  • Background
    Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"