Anti-Survivin (8B9) Mouse antibody

Cat.#: 168236

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Product Information

  • Product Name
    Anti-Survivin (8B9) Mouse antibody
  • Documents
  • Description
    Survivin (8B9) Mouse monoclonal antibody
  • Tested applications
    WB, IHC-P
  • Species reactivity
    Human, Rat
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Recombinant Protein of Survivin
  • Clonality
    Monoclonal
  • Formulation
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000-2000

    IHC: 1/200-500

  • Validations

    Western blot analysis of 1) Hela, 2) 293, 3) PC12 using Survivin Monoclonal Antibody.

    Western blot analysis of 1) Hela, 2) 293, 3) PC12 using Survivin Monoclonal Antibody.

    Immunohistochemical analysis of paraffin-embedded human colon caricnoma using Survivin Monoclonal Antibody.

    Immunohistochemical analysis of paraffin-embedded human colon caricnoma using Survivin Monoclonal Antibody.

    Western blot detection of Survivin in COS7,Jurkat and Hela cell lysates using Survivin mouse mAb (1:1000 diluted).Predicted band size:16kDa.Observed band size:16kDa.

    Western blot detection of Survivin in COS7,Jurkat and Hela cell lysates using Survivin mouse mAb (1:1000 diluted).Predicted band size:16kDa.Observed band size:16kDa.

  • Background
    Swiss-Prot Acc.O15392.Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"