Anti-SETD7/SET7/9 antibody

Cat.#: 106134

Special Price 145.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Anti-SETD7/SET7/9 antibody
  • Documents
  • Description
    Rabbit polyclonal to SETD7/SET7/9
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human SETD7 / SET7 / 9
  • Alternative names
    1600028F23Rik antibody; FLJ21193 antibody; H3K4MT antibody; KIAA1717 antibody; KMT7 antibody; KMT7 antibody; mKIAA1717 antibody; SET7 antibody; Set7 antibody; Set7/9 antibody; SET7/9 antibody; SET9 antibody; Setd7 antibody; SETD7 antibody; KMT7 antibody; SET7 antibody; SET9 antibody; SET7/9 antibody; KMT7 antibody; Set7 antibody; H3K4MT antibody; Set7/9 antibody; mKIAA1717 antibody; 1600028F23Rik antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human SETD7 / SET7 / 9 (rh SETD7 / SET7 / 9; NP_085151.1; Asp2-Lys366). SETD7 / SET7 / 9 specific IgG was purified by Human SETD7 / SET7 / 9 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 2-5 μg/ml

    ELISA:0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human SETD7 / SET7 / 9. The detection limit for Human SETD7 / SET7 / 9 is 0.00975 ng/well.

    IP: 1-4 μg/mg of lysate

  • Validations

    SETD7 / SET7 / 9 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    SETD7 / SET7 / 9 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    SETD7 / SET7 / 9 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation

    SETD7 / SET7 / 9 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation

  • Background
    Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine methyltransferase family and SET7 subfamily. SETD7 is widely expressed and expressed in pancreatic islets. SETD7 contains three MORN repeats and one SET domain. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. As a protein lysine methyltransferase (PKMT), SETD7 also has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding in substrate proteins. The mono-methyltransferase activity of SETD7 is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction. SETD7 is also a novel coactivator of NF-kappaB and plays a role in inflammation and diabetes.
  • References
    • Wang, H. et al., 2002, Mol Cell 8 (6): 1207-17. 
    • Jacobs, SA. et al., 2002, Nat. Struct. Biol. 9 (11): 833-8. 
    • Xiao B, et al., 2003, Nature. 421 (6923): 652-6.
    • Martens, JH. et al., 2003, Mol. Cell. Biol. 23: 1808-1816.
    • Couture, JF. et al., 2006, Nat Struct Mol Biol  13 (2): 140-6.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"