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Anti-RUNX3 (4H2) Mouse antibody

Cat.#: 168490

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Product Information

  • Product Name
    Anti-RUNX3 (4H2) Mouse antibody
  • Documents
  • Description
    RUNX3 (4H2) Mouse monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC
  • Species reactivity
    Human, Mouse
  • Isotype
    Mouse IgG2b
  • Preparation
    Antigen: Purified recombinant fragment of human RUNX3 (AA:186-252) expressed in E. Coli.
  • Clonality
    Monoclonal
  • Formulation
    Purified antibody in PBS with 0.05% sodium azide
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500 - 1/2000

    IHC: 1/200 - 1/1000

    ICC: 1/200 - 1/1000

    FC: 1/200 - 1/400

    ELISA: 1/10000

  • Validations

    Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using RUNX3 mouse mAb with DAB staining.

    Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using RUNX3 mouse mAb with DAB staining.

    Western blot analysis using RUNX3 mAb against HEK293 (1) and RUNX3 (AA: 186-252)-hIgGFc transfected HEK293 (2) cell lysate.

    Western blot analysis using RUNX3 mAb against HEK293 (1) and RUNX3 (AA: 186-252)-hIgGFc transfected HEK293 (2) cell lysate.

    Western blot detection of RUNX3/AML2 in C6 cell lysates using RUNX3/AML2 mouse mAb (1:5000 diluted).Predicted band size:44KDa.Observed band size:43~48KDa.

    Western blot detection of RUNX3/AML2 in C6 cell lysates using RUNX3/AML2 mouse mAb (1:5000 diluted).Predicted band size:44KDa.Observed band size:43~48KDa.

    Flow cytometric analysis of NIH3T3 cells using RUNX3 mouse mAb (green) and negative control (red).

    Flow cytometric analysis of NIH3T3 cells using RUNX3 mouse mAb (green) and negative control (red).

  • Background
    Swiss-Prot Acc.Q13761.This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

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