Anti-METAP1 antibody

Cat.#: 104969

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Product Information

  • Product Name
    Anti-METAP1 antibody
  • Documents
  • Description
    Rabbit polyclonal to METAP1
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human METAP1
  • Alternative names
    MAP1A antibody; MetAP1A antibody; AW047992 antibody; mKIAA0094 antibody; 1700029C17Rik antibody; 1700029C17Rik antibody; AW047992 antibody; DKFZp781C0419 antibody; KIAA0094 antibody; KIAA0094 antibody; METAP1 antibody; METAP1 antibody; Methionyl Aminopeptidase 1 antibody; Methionyl Aminopeptidase 1 antibody; mKIAA0094 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human METAP1 (rh METAP1 ; NP_055958.2; His52-Phe386). METAP1 specific IgG was purified by Human METAP1 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 5-20 μg/ml

    ELISA: 0.1-0.2 μg/mL μg/ml

    This antibody can be used at 0.1-0.2 μg/mL μg/ml with the appropriate secondary reagents to detect Human METAP1.

    IP: 1-4 μg/mg of lysate

  • Validations

    METAP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    METAP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    METAP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation

    METAP1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation

  • Background
    Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. As a member of the M24 family of metalloproteases, METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"