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Product Name
Anti-MAPK6/ERK-3 Rabbit antibody
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Description
MAPK6/ERK-3 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
ERK3; PRKM6; p97MAPK; HsT17250 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human MAPK6
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/5000
IHC: 1/20
FC: 1/20-1/100
IP: 1/20
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Validations
Western blot detection of MAPK6 in 3T3,Hela cell lysates using MAPK6 Rabbit pAb(1:1000 diluted).Predicted band size:83kDa.Observed band size:105kDa.
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Background
Swiss-Prot Acc.Q16659.Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle .
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"