Anti-MANF antibody

Anti-MANF antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to MANF

ELISA, WB, IP

Human MANF / ARMET

ARMET antibody; Armet antibody; D17914 antibody; AA407711 antibody; AA408789 antibody; AA673178 antibody; D18Mgi17 antibody; 3230402M22Rik antibody; ARP antibody; 3230402M22Rik antibody; AA407711 antibody; AA408789 antibody; AA673178 antibody; Armet antibody; ARMET antibody; ARP antibody; D17914 antibody; D18Mgi17 antibody; Manf antibody; MANF antibody; MGC142148 antibody; MGC142150 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human MANF / ARMET (rh MANF / ARMET; NP_006001.3; Met 1-Leu 179). MANF / ARMET specific IgG was purified by Human MANF / ARMET affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF and ARMET, is a secreted protein which belongs to the ARMET family. ARMET selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. ARMET enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. ARMET inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus and cerebellar Purkinje cells. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

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• Gevaert K., et al., 2003, Nat. Biotechnol. 21:566-569.
• Petrova P., et al., 2003, J. Mol. Neurosci. 20:173-188.
• Lindholm, P. et al., 2008, Mol Cell Neurosci. 39 (3):356-71.
• Airavaara, M. et al., 2010, Exp Neurol. 225 (1):104-13.