Anti-IL20RA/IL-20RA antibody

Cat.#: 103804

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Product Information

  • Product Name
    Anti-IL20RA/IL-20RA antibody
  • Documents
  • Description
    Rabbit monoclonal to IL20RA/IL-20RA
  • Tested applications
    ELISA, IHC-P
  • Species reactivity
    Human IL20RA / IL-20RA
    No cross-reactivity in ELISA with Human IFNgR1; Human IL10RB
  • Alternative names
    E230031K19 antibody; FLJ40993 antibody; IL-20R1 antibody; Il20ra antibody; IL20RA antibody; RP11-204P2.1 antibody; ZCYTOR7 antibody; CRF2-8 antibody; IL-20R1 antibody; IL-20RA antibody; IL-20R-alpha antibody; E230031K19 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human IL20RA / IL-20RA (rh IL20RA / IL-20RA; NP_055247.21; Met 1-Lys 250).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.5-1 μg/mL

    This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human IL20Ra.

    IHC-P: 1-10 μg/mL

  • Validations

    IL20RA / IL-20RA Antibody, Rabbit MAb, Immunohistochemistry

    IL20RA / IL-20RA Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of human IL20Ra in human skin with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to stratified squamous epithelium.

  • Background
    Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA forms heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. All three are capable of signaling through IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.
  • References
    • Parrish-Novak J, et al. (2002) Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 277(49): 47517-23.
    • Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5): 445-51.
    • Blumberg H, et al. (2001) Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 104(1): 9-19.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"