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Anti-DOPA Decarboxylase/DDC antibody

Cat.#: 100799

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Product Information

  • Product Name
    Anti-DOPA Decarboxylase/DDC antibody
  • Documents
  • Description
    Rabbit polyclonal to DOPA Decarboxylase/DDC
  • Tested applications
    ELISA, WB, IHC-P
  • Species reactivity
    Mouse DOPA Decarboxylase / DDC
  • Alternative names
    AADC antibody; Aadc antibody; Aadc antibody; AADC antibody; Ddc antibody; DDC antibody; DOPA Decarboxylase antibody; DOPA Decarboxylase antibody; RP23-373H2.3 antibody
  • Immunogen
    Mouse DOPA Decarboxylase/DDC (His Tag) recombinant protein
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse DOPA Decarboxylase / DDC (rh DOPA Decarboxylase / DDC; O88533; Met1-Glu480). DOPA Decarboxylase / DDC specific IgG was purified by Mouse DOPA Decarboxylase / DDC affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 5-10 μg/ml

    ELISA:0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse DOPA Decarboxylase / DDC. The detection limit for Mouse DOPA Decarboxylase / DDC is < 0.039 ng/well.

    IHC-P: 0.1-1 μg/ml

  • Validations

    DOPA Decarboxylase / DDC Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    DOPA Decarboxylase / DDC Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    DOPA Decarboxylase / DDC Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    DOPA Decarboxylase / DDC Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

  • Background
    Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson's disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.
  • References
    • Ichinose, H. et al.,1989,Biochem. Biophys. Res. Commun. 164: 1024-1030.
    • Lisa, J. S. et al., 1992, Genomics 13: 469-471.
    • Moore, P. S. et al.,1996, Biochem. J. 315:249-256.
    • Bertoldi, M. et al., 2003, Biochim. Biophys. Acta. 1647:42-47.
    • Vassilacopoulou, D. et al., 2004, Neurochem. Res. 29: 1817-1823.
    • Ma, J.Z., et al., 2005, Hum. Mol. Genet. 14: 1691-1698.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"