Anti-Bcl10 Rabbit antibody

Cat.#: 167917

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Product Information

  • Product Name
    Anti-Bcl10 Rabbit antibody
  • Documents
  • Description
    Bcl10 Rabbit monoclonal antibody
  • Tested applications
    WB, ICC/IF, IP
  • Species reactivity
    Human
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human Bcl10
  • Clonality
    Monoclonal
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    ICC/IF: 1/50

    IP: 1/20

  • Validations

    Western blot detection of Bcl10 in A549,MCF-7,293T cell lysates using Bcl10 Rabbit mAb(1:1000 diluted).Predicted band size:26kDa.Observed band size:26kDa.

    Western blot detection of Bcl10 in A549,MCF-7,293T cell lysates using Bcl10 Rabbit mAb(1:1000 diluted).Predicted band size:26kDa.Observed band size:26kDa.

  • Background
    This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"