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Product Name
ANGPTL2 antibody
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Description
ANGPTL2 Rabbit Polyclonal antibody. Positive IHC detected in human heart tissue, human spleen tissue. Positive IP detected in mouse testis tissue. Positive WB detected in mouse small intestine tissue, mouse heart tissue, mouse spleen tissue, mouse testis tissue. Observed molecular weight by Western-blot: 57-64 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
angiopoietin like 2 antibody; Angiopoietin like protein 2 antibody; Angiopoietin related protein 2 antibody; ANGPTL2 antibody; ARP2 antibody; HARP antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ANGPTL2 recombinant protein (Accession Number: NM_012098). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse small intestine tissue were subjected to SDS PAGE followed by western blot with Catalog No:108056(ANGPTL2 antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human heart using Catalog No:108056(ANGPTL2 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human heart using Catalog No:108056(ANGPTL2 antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-ANGPTL2 (IP:Catalog No:108056, 4ug; Detection:Catalog No:108056 1:500) with mouse testis tissue lysate 4800ug.
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Background
ANGPTL2 (angiopoietin-like 2), a member of the Angptl protein family, is predominantly secreted from adipose tissue and the heart. ANGPTL2 consists of an N-terminus with a conserved coiled-coil domain, two glycosylation sites and a C-terminus with a conserved fibrinogen-like domain. It is a key adipocyte-derived inflammatory mediator that links obesity to systemic insulin resistance. ANGPTL2 may play an important role in the pathogenesis of diabetic glomerulopathy.
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References
- Sato R, Yamasaki M, Hirai K. Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells. Oncology reports. 33(1):58-66. 2015.
- Wang L, Geng T, Guo X. Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer. Molecular medicine reports. 11(4):2789-96. 2015.
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