Alpha-1-Antitrypsin antibody

Alpha-1-Antitrypsin antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Alpha-1-Antitrypsin Mouse Monoclonal antibody. Positive IP detected in human plasma tissue. Positive WB detected in HepG2 cells. Positive IF detected in HepG2 cells. Positive IHC detected in human liver tissue. Observed molecular weight by Western-blot: 51 kDa

ELISA, WB, IHC, IF, IP

Human; other species not tested.

A1A antibody; A1AT antibody; AAT antibody; Alpha 1 antiproteinase antibody; Alpha 1 antitrypsin antibody; Alpha 1 protease inhibitor antibody; PI1 antibody; PRO2209 antibody; PRO2275 antibody; Serpin A1 antibody; SERPINA1 antibody; SPAAT antibody; α1-antitrypsin antibody

Mouse IgG1

This antibody was obtained by immunization of Alpha-1-Antitrypsin recombinant protein (Accession Number: NM_001127700). Purification method: Protein G purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.