ALK,CD246 antibody

Cat.#: 107112

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Product Information

  • Product Name
    ALK,CD246 antibody
  • Documents
  • Description
    ALK,CD246 Mouse Monoclonal antibody. Positive IHC detected in human lymphoma tissue. Positive WB detected in Recombinant protein.
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    ALK antibody; ALK tyrosine kinase receptor antibody; ALK antibody; CD246 antibody; Anaplastic lymphoma kinase antibody; CD246 antibody; TFG/ALK antibody
  • Immunogen
  • Isotype
    Mouse IgG2a
  • Preparation
    This antibody was obtained by immunization of ALK,CD246 recombinant protein (Accession Number: NM_004304). Purification method: Protein A purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    Immunohistochemistry of paraffin-embedded human lymphoma slide using (ALK,CD246 Antibody) at dilution of 1:50

    Immunohistochemistry of paraffin-embedded human lymphoma slide using (ALK,CD246 Antibody) at dilution of 1:50

    Immunohistochemistry of paraffin-embedded human lymphoma slide using (ALK,CD246 Antibody) at dilution of 1:50

    Immunohistochemistry of paraffin-embedded human lymphoma slide using (ALK,CD246 Antibody) at dilution of 1:50

    Recombinant protein were subjected to SDS PAGE followed by western blot with Catalog No:107572(ALK,CD246 Antibody) at dilution of 1:1000

    Recombinant protein were subjected to SDS PAGE followed by western blot with Catalog No:107572(ALK,CD246 Antibody) at dilution of 1:1000

  • Background
    ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).

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