ALDH1L2 antibody

Cat.#: 107965

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Product Information

  • Product Name
    ALDH1L2 antibody
  • Documents
  • Description
    ALDH1L2 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas tissue, human heart tissue. Positive WB detected in mouse kidney tissue, HEK-293 cells. Observed molecular weight by Western-blot: 102 kDa, 89 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    ALDH1L2 antibody; DKFZp686A16126 antibody; DKFZp686M064 antibody; FLJ38508 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of ALDH1L2 recombinant protein (Accession Number: BC103935). Purification method: Antigen Affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    mouse kidney tissue were subjected to SDS PAGE followed by western blot with Catalog No:107965(ALDH1L2 antibody) at dilution of 1:1000

    mouse kidney tissue were subjected to SDS PAGE followed by western blot with Catalog No:107965(ALDH1L2 antibody) at dilution of 1:1000

    Immunohistochemistry of paraffin-embedded human pancreas slide using Catalog No:107965(ALDH1L2 Antibody) at dilution of 1:50

    Immunohistochemistry of paraffin-embedded human pancreas slide using Catalog No:107965(ALDH1L2 Antibody) at dilution of 1:50

    Immunohistochemistry of paraffin-embedded human pancreas slide using Catalog No:107965(ALDH1L2 Antibody) at dilution of 1:50

    Immunohistochemistry of paraffin-embedded human pancreas slide using Catalog No:107965(ALDH1L2 Antibody) at dilution of 1:50

  • Background
    ALDH1L2(Aldehyde dehydrogenase family 1 member L2) is also named as mitochondrial 10-FTHFDH, mtFDH and belongs to the aldehyde dehydrogenase family and ALDH1L subfamily. The ALDH1L2 gene has three transcriptional variants with the molecular weight of 102 kDa, 42 kDa and 89 kDa(PMID:19823103). It is a mitochondrial enzyme, a likely source of CO2 production from 10-formyltetrahydrofolate in mitochondria and playing an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell(PMID: 20498374). It also has dehydrogenase/hydrolase activities similar to cytosolic FDH (ALDH1L1). The native ALDH1L2 has been reported to exist as a dimer or tetramer(PMID:7822273).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"