AIRE antibody

AIRE antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

AIRE Rabbit Polyclonal antibody. Positive IHC detected in human stomach tissue. Positive WB detected in L02 cells, human plasma tissue, human spleen tissue, mouse thymus tissue, U-937 cells. Observed molecular weight by Western-blot: 65-70 kDa

ELISA, WB, IHC

Human, Mouse; other species not tested.

AIRE antibody; AIRE1 antibody; APECED antibody; APECED protein antibody; APS1 antibody; APSI antibody; autoimmune regulator antibody; PGA1 antibody

Rabbit IgG

This antibody was obtained by immunization of AIRE recombinant protein (Accession Number: NM_000658). Purification method: Antigen Affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The function of the protein is not well defined, however it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE3 includes the same exon 1-8-9 sequences as found in AIRE2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized. The resulting protein products of these splice variants differ significantly. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).