ADAM8 antibody

ADAM8 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ADAM8 Rabbit Polyclonal antibody. Positive WB detected in BxPC-3 cells, mouse pancreas tissue. Positive IHC detected in human tonsillitis tissue, human pancreas tissue. Observed molecular weight by Western-blot: 65 kDa

ELISA, WB, IHC

Human, Mouse; other species not tested.

ADAM metallopeptidase domain 8 antibody; ADAM8 antibody; ADAM8 protein antibody; CD156 antibody; MS2 antibody

Rabbit IgG

This antibody was obtained by immunization of ADAM8 recombinant protein (Accession Number: NM_001109). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

ADAMs are a large family of transmembrane proteins that are involved in proteolysis, making them candidates for mediating the remodeling of the extracellular matrix(ECM). ADAM8, one of the members of the ADAM family, is overexpressed in various human tumors. It has been shown previously that hypoxia influences the expression of some ADAM proteins. The protein found to be expressed in two active forms(90 kDa and 60 kDa): potential shedding protein and remnant protein in the pancreatic tissues under chronic pancreatitis and pancreatic cancer(PMID:18566576). The full length protein has a signal peptide and four glycosylation sites. This antibody is specific to ADAM8.

• Zhang Y, Tan YF, Jiang C, Zhang K, Zha TZ, Zhang M. High ADAM8 expression is associated with poor prognosis in patients with hepatocellular carcinoma. Pathology oncology research : POR. 19(1):79-88. 2013.