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ADAM17-Specific antibody

Cat.#: 107763

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Product Information

  • Product Name
    ADAM17-Specific antibody
  • Documents
  • Description
    ADAM17-Specific Rabbit Polyclonal antibody. Positive WB detected in human placenta tissue. Positive IHC detected in human pancreas cancer tissue. Observed molecular weight by Western-blot: 29 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    ADAM 17 antibody; ADAM17 antibody; CD156b antibody; cSVP antibody; Snake venom like protease antibody; TACE antibody; TNF alpha convertase antibody; TNF alpha converting enzyme antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_003183). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:107763(ADAM17-Specific antibody) at dilution of 1:500

    human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:107763(ADAM17-Specific antibody) at dilution of 1:500

    Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:107763(ADAM17-Specific Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:107763(ADAM17-Specific Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:107763(ADAM17-Specific Antibody) at dilution of 1:200 (under 40x lens).

    Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:107763(ADAM17-Specific Antibody) at dilution of 1:200 (under 40x lens).

  • Background
    The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"